Drug interactions
Metformin-sitagliptin + Nilotinib
Severity: Moderate
Metformin-sitagliptin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is associated with hyperglycemia and can worsen glycemic control in diabetic patients. This may counteract the effect of metformin and sitagliptin.
What this interaction means in plain words
Metformin-sitagliptin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Nilotinib-associated hyperglycemia has an incompletely understood mechanism that opposes antidiabetic therapy.
What to do
Monitor fasting glucose and HbA1c during nilotinib treatment and intensify antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Nilotinib?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is associated with hyperglycemia and can worsen glycemic control in diabetic patients. This may counteract the effect of metformin and sitagliptin.
How serious is the interaction between Metformin-sitagliptin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c during nilotinib treatment and intensify antidiabetic therapy as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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