Drug interactions
Metformin-sitagliptin + Quinine
Severity: Minor
Metformin-sitagliptin and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin and quinine are both organic cations eliminated by renal tubular secretion, and they may compete for this pathway. Exposure to either drug could rise modestly, though the clinical impact is generally small.
What this interaction means in plain words
Metformin-sitagliptin and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Quinine belongs to Anti Parasitic.
Why it happens
Competition for renal tubular secretion via organic cation transporters (OCT2/MATE).
What to do
No routine adjustment is needed; monitor for quinine adverse effects such as cinchonism and for blood glucose, since quinine can also cause hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Quinine?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin and quinine are both organic cations eliminated by renal tubular secretion, and they may compete for this pathway. Exposure to either drug could rise modestly, though the clinical impact is generally small.
How serious is the interaction between Metformin-sitagliptin and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for quinine adverse effects such as cinchonism and for blood glucose, since quinine can also cause hypoglycemia.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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