Drug interactions
Metformin-sitagliptin + Selegiline
Severity: Minor
Metformin-sitagliptin and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline has no well-established pharmacokinetic interaction with metformin or sitagliptin. MAO inhibitors may enhance the hypoglycemic effect of antidiabetic drugs, though risk is low with these agents.
What this interaction means in plain words
Metformin-sitagliptin and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
The mechanism is not well established; MAO inhibition may influence glucose regulation.
What to do
Monitor blood glucose when starting or stopping selegiline and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Selegiline?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selegiline has no well-established pharmacokinetic interaction with metformin or sitagliptin. MAO inhibitors may enhance the hypoglycemic effect of antidiabetic drugs, though risk is low with these agents.
How serious is the interaction between Metformin-sitagliptin and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping selegiline and adjust antidiabetic doses if needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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