Drug interactions
Metformin-sitagliptin + Trandolapril
Severity: Moderate
Metformin-sitagliptin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They can also reduce renal function, raising the risk of metformin accumulation.
What this interaction means in plain words
Metformin-sitagliptin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity and can reduce renal function, decreasing metformin clearance.
What to do
Monitor blood glucose and renal function, especially when starting trandolapril, and adjust metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metformin-sitagliptin and Trandolapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-sitagliptin
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Metformin-sitagliptin with Trandolapril?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They can also reduce renal function, raising the risk of metformin accumulation.
How serious is the interaction between Metformin-sitagliptin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, especially when starting trandolapril, and adjust metformin if renal function declines.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
