Drug interactions
Metformin-sitagliptin + Triamterene
Severity: Moderate
Metformin-sitagliptin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene and metformin are both cationic drugs cleared by renal tubular secretion, so triamterene may raise metformin exposure. Higher metformin levels could increase the risk of gastrointestinal effects and, rarely, lactic acidosis, especially with reduced kidney function.
What this interaction means in plain words
Metformin-sitagliptin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Competition for renal tubular secretion via OCT2 and MATE transporters, reducing metformin clearance.
What to do
Monitor renal function and glycemic control, and watch for signs of metformin accumulation. Reduce the metformin dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Metformin-sitagliptin with Triamterene?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene and metformin are both cationic drugs cleared by renal tubular secretion, so triamterene may raise metformin exposure. Higher metformin levels could increase the risk of gastrointestinal effects and, rarely, lactic acidosis, especially with reduced kidney function.
How serious is the interaction between Metformin-sitagliptin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glycemic control, and watch for signs of metformin accumulation. Reduce the metformin dose if renal function declines.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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