Drug interactions
Methadone + Metoclopramide intranasal
Severity: Moderate
Methadone and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause extrapyramidal effects and sedation, and opioids antagonize its prokinetic action by slowing gastric emptying. The combination can also add to CNS depression, though the clinical interaction is modest.
What this interaction means in plain words
Methadone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-induced reduction in gut motility opposes metoclopramide, with additive CNS depressant effects.
What to do
Monitor for reduced antiemetic or prokinetic efficacy and for excess sedation. Consider an alternative antiemetic if response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Methadone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause extrapyramidal effects and sedation, and opioids antagonize its prokinetic action by slowing gastric emptying. The combination can also add to CNS depression, though the clinical interaction is modest.
How serious is the interaction between Methadone and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiemetic or prokinetic efficacy and for excess sedation. Consider an alternative antiemetic if response is poor.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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