Drug interactions
Methadone + Molindone
Severity: Moderate
Methadone and Molindone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone may add to antipsychotic-related QT effects and sedation, and both have been linked with serotonergic or dopaminergic toxicity in rare cases. The risk of serious serotonin syndrome or neuroleptic malignant syndrome is low but possible. Additive CNS depression may also occur.
What this interaction means in plain words
Methadone and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on CNS depression and cardiac repolarization, with possible serotonergic and dopaminergic overlap.
What to do
Monitor for sedation, mental status change, rigidity and hyperthermia, and obtain an ECG if other QT risk factors are present. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Molindone?
MediHelp rates the interaction as moderate. Methadone and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methadone may add to antipsychotic-related QT effects and sedation, and both have been linked with serotonergic or dopaminergic toxicity in rare cases. The risk of serious serotonin syndrome or neuroleptic malignant syndrome is low but possible. Additive CNS depression may also occur.
How serious is the interaction between Methadone and Molindone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, mental status change, rigidity and hyperthermia, and obtain an ECG if other QT risk factors are present. Correct electrolyte abnormalities.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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