Drug interactions
Methadone + Motherwort
Severity: Moderate
Methadone and Motherwort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Motherwort has traditional sedative properties and may add to the central nervous system depression produced by methadone. Evidence is limited, but excess drowsiness and slowed breathing are plausible.
What this interaction means in plain words
Methadone and Motherwort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical additive sedative effect; the herb's constituents are poorly characterized.
What to do
Advise patients to avoid motherwort or other sedating herbal products while taking methadone. If used, monitor for excessive drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Motherwort?
MediHelp rates the interaction as moderate. Methadone and Motherwort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Motherwort has traditional sedative properties and may add to the central nervous system depression produced by methadone. Evidence is limited, but excess drowsiness and slowed breathing are plausible.
How serious is the interaction between Methadone and Motherwort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid motherwort or other sedating herbal products while taking methadone. If used, monitor for excessive drowsiness.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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