Drug interactions
Methadone + Moxonidine
Severity: Moderate
Methadone and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause drowsiness and lowered blood pressure, which may be exaggerated by methadone. Together they can increase sedation and dizziness or orthostatic hypotension.
What this interaction means in plain words
Methadone and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central sedative and hypotensive effects.
What to do
Monitor blood pressure and sedation after starting or adjusting either drug. Counsel the patient to rise slowly and avoid driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Moxonidine?
MediHelp rates the interaction as moderate. Methadone and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that can cause drowsiness and lowered blood pressure, which may be exaggerated by methadone. Together they can increase sedation and dizziness or orthostatic hypotension.
How serious is the interaction between Methadone and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation after starting or adjusting either drug. Counsel the patient to rise slowly and avoid driving until response is known.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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