Drug interactions
Methadone + Octreotide
Severity: Moderate
Methadone and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and octreotide can also cause bradycardia, which increases the arrhythmia risk. The combination may raise the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Methadone and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methadone belongs to Musculoskeletal; Octreotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia as a further contributor.
What to do
Check a baseline ECG and repeat after starting or changing doses. Correct electrolyte disturbances and monitor heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Methadone with Octreotide?
MediHelp rates the interaction as moderate. Methadone and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and octreotide can also cause bradycardia, which increases the arrhythmia risk. The combination may raise the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Methadone and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and repeat after starting or changing doses. Correct electrolyte disturbances and monitor heart rate.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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