Drug interactions
Methadone + Olodaterol inhaled
Severity: Moderate
Methadone and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone prolongs the QT interval, and beta2-agonists can cause hypokalemia and tachycardia, which may further increase arrhythmia risk. Systemic exposure to inhaled olodaterol is low, so the risk is generally small but relevant in patients with other cardiac risk factors.
What this interaction means in plain words
Methadone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization and beta2-mediated hypokalemia.
What to do
Check potassium and magnesium and obtain an ECG in patients with additional QT risk factors or high methadone doses. Keep olodaterol at the labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Methadone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methadone prolongs the QT interval, and beta2-agonists can cause hypokalemia and tachycardia, which may further increase arrhythmia risk. Systemic exposure to inhaled olodaterol is low, so the risk is generally small but relevant in patients with other cardiac risk factors.
How serious is the interaction between Methadone and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and obtain an ECG in patients with additional QT risk factors or high methadone doses. Keep olodaterol at the labeled dose.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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