Drug interactions
Methadone + Olopatadine intranasal
Severity: Minor
Methadone and Olopatadine intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and together with methadone may add to CNS depression and psychomotor impairment. Systemic absorption is low, so the effect is generally modest.
What this interaction means in plain words
Methadone and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive sedative effects of an antihistamine and an opioid.
What to do
Counsel patients about drowsiness and caution when driving or operating machinery. Reduce olopatadine use if sedation is noticeable.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Olopatadine intranasal?
MediHelp rates the interaction as minor. Methadone and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal olopatadine can cause somnolence, and together with methadone may add to CNS depression and psychomotor impairment. Systemic absorption is low, so the effect is generally modest.
How serious is the interaction between Methadone and Olopatadine intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and caution when driving or operating machinery. Reduce olopatadine use if sedation is noticeable.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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