Drug interactions
Methadone + Sage
Severity: Minor
Methadone and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage is a herbal product with reported mild sedative properties, so it could add to the CNS depression caused by methadone. The clinical significance is uncertain and based on theoretical reasoning rather than good clinical data.
What this interaction means in plain words
Methadone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depressant effects; the mechanism for sage is not firmly established.
What to do
Counsel the patient to report excessive drowsiness and to avoid concentrated sage supplements or essential oils while on methadone. Monitor sedation and respiratory status if the combination is used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Sage?
MediHelp rates the interaction as minor. Methadone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage is a herbal product with reported mild sedative properties, so it could add to the CNS depression caused by methadone. The clinical significance is uncertain and based on theoretical reasoning rather than good clinical data.
How serious is the interaction between Methadone and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report excessive drowsiness and to avoid concentrated sage supplements or essential oils while on methadone. Monitor sedation and respiratory status if the combination is used regularly.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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