Drug interactions
Methadone + Scullcap
Severity: Moderate
Methadone and Scullcap: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scullcap has reputed sedative properties and could add to the CNS depression produced by methadone. Evidence is limited and largely theoretical.
What this interaction means in plain words
Methadone and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive CNS depression; scullcap may act on GABA receptors.
What to do
Discourage use of sedative herbal products with methadone and monitor for excess drowsiness if taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Scullcap?
MediHelp rates the interaction as moderate. Methadone and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scullcap has reputed sedative properties and could add to the CNS depression produced by methadone. Evidence is limited and largely theoretical.
How serious is the interaction between Methadone and Scullcap?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discourage use of sedative herbal products with methadone and monitor for excess drowsiness if taken.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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