Drug interactions
Methadone + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Methadone and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta-agonist that can have cardiovascular effects, including QT changes and tachycardia. Methadone also prolongs QTc, so a small additive effect is possible, although systemic exposure from inhaled doses is low.
What this interaction means in plain words
Methadone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive effects on cardiac repolarization and beta-adrenergic stimulation.
What to do
Use at labeled doses and monitor for palpitations and QTc prolongation in patients on higher-dose methadone or with other arrhythmia risk factors. Correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Methadone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta-agonist that can have cardiovascular effects, including QT changes and tachycardia. Methadone also prolongs QTc, so a small additive effect is possible, although systemic exposure from inhaled doses is low.
How serious is the interaction between Methadone and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use at labeled doses and monitor for palpitations and QTc prolongation in patients on higher-dose methadone or with other arrhythmia risk factors. Correct hypokalemia.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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