Drug interactions
Methadone + Yohimbine
Severity: Minor
Methadone and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is a stimulant alpha-2 antagonist that may partly counter opioid sedation and can precipitate withdrawal-like symptoms such as anxiety, hypertension and tachycardia. The net effect is unpredictable.
What this interaction means in plain words
Methadone and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic opposition: alpha-2 blockade increases noradrenergic activity, counteracting opioid effects; not well characterized.
What to do
Be aware of possible withdrawal-like symptoms and blood pressure rise. Avoid yohimbine in patients on methadone where possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methadone and Yohimbine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Methadone with Yohimbine?
MediHelp rates the interaction as minor. Methadone and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is a stimulant alpha-2 antagonist that may partly counter opioid sedation and can precipitate withdrawal-like symptoms such as anxiety, hypertension and tachycardia. The net effect is unpredictable.
How serious is the interaction between Methadone and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of possible withdrawal-like symptoms and blood pressure rise. Avoid yohimbine in patients on methadone where possible.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
