Drug interactions
Methotrexate + Sotorasib
Severity: Moderate
Methotrexate and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein inhibitor and may increase, not decrease, exposure to P-gp substrates such as methotrexate. Higher levels could add to methotrexate toxicity.
What this interaction means in plain words
Methotrexate and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-glycoprotein efflux, potentially reducing methotrexate elimination.
What to do
Monitor blood counts and liver and renal function during combined use. Lower the methotrexate dose if signs of toxicity develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Methotrexate with Sotorasib?
MediHelp rates the interaction as moderate. Methotrexate and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-glycoprotein inhibitor and may increase, not decrease, exposure to P-gp substrates such as methotrexate. Higher levels could add to methotrexate toxicity.
How serious is the interaction between Methotrexate and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver and renal function during combined use. Lower the methotrexate dose if signs of toxicity develop.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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