Drug interactions
Methotrexate + Tetracycline
Severity: Moderate
Methotrexate and Tetracycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracyclines have been reported to raise methotrexate exposure, mainly with high-dose therapy. This may increase myelosuppression, mucositis and kidney injury.
What this interaction means in plain words
Methotrexate and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Tetracycline belongs to Anti Bacterial.
Why it happens
Possible reduced renal elimination of methotrexate; the mechanism is not firmly established.
What to do
Avoid the combination with high-dose methotrexate if possible. If needed, monitor methotrexate levels, renal function and blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Methotrexate with Tetracycline?
MediHelp rates the interaction as moderate. Methotrexate and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetracyclines have been reported to raise methotrexate exposure, mainly with high-dose therapy. This may increase myelosuppression, mucositis and kidney injury.
How serious is the interaction between Methotrexate and Tetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination with high-dose methotrexate if possible. If needed, monitor methotrexate levels, renal function and blood counts.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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