Drug interactions
Methotrexate + Tisagenlecleucel
Severity: Major
Methotrexate and Tisagenlecleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate is immunosuppressive and may impair the expansion and persistence of CAR-T cells, reducing efficacy. Combined with the profound lymphodepletion and cytopenias after CAR-T therapy, it may also increase infection risk.
What this interaction means in plain words
Methotrexate and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methotrexate belongs to Oncology; Tisagenlecleucel belongs to Oncology.
Why it happens
Additive immunosuppression and antiproliferative effects of methotrexate may blunt CAR-T cell proliferation and function.
What to do
Avoid methotrexate in the period around leukapheresis and CAR-T infusion unless clearly needed. If it must be used, monitor closely for infection and CAR-T response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methotrexate and Tisagenlecleucel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Methotrexate with Tisagenlecleucel?
MediHelp rates the interaction as major. Methotrexate and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methotrexate is immunosuppressive and may impair the expansion and persistence of CAR-T cells, reducing efficacy. Combined with the profound lymphodepletion and cytopenias after CAR-T therapy, it may also increase infection risk.
How serious is the interaction between Methotrexate and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid methotrexate in the period around leukapheresis and CAR-T infusion unless clearly needed. If it must be used, monitor closely for infection and CAR-T response.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
