Drug interactions
Anti-thymocyte + Tisagenlecleucel
Severity: Major
Anti-thymocyte and Tisagenlecleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-thymocyte globulin depletes T cells and can destroy infused CAR-T cells, reducing their expansion and efficacy. It also adds to infection risk in patients who are already immunocompromised.
What this interaction means in plain words
Anti-thymocyte and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anti-thymocyte belongs to Miscellaneous; Tisagenlecleucel belongs to Oncology.
Why it happens
Lympholytic activity of anti-thymocyte globulin against CAR-T cells and additive immunosuppression.
What to do
Avoid anti-thymocyte globulin around CAR-T infusion and wait an adequate washout interval before infusion. Where it is needed, for example for severe toxicity, monitor for infection and CAR-T persistence.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Anti-thymocyte with Tisagenlecleucel?
MediHelp rates the interaction as major. Anti-thymocyte and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anti-thymocyte globulin depletes T cells and can destroy infused CAR-T cells, reducing their expansion and efficacy. It also adds to infection risk in patients who are already immunocompromised.
How serious is the interaction between Anti-thymocyte and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid anti-thymocyte globulin around CAR-T infusion and wait an adequate washout interval before infusion. Where it is needed, for example for severe toxicity, monitor for infection and CAR-T persistence.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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