Drug interactions
Methoxyflurane + Pseudoephedrine
Severity: Moderate
Methoxyflurane and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane can sensitize the myocardium to catecholamines, which may lead to ventricular arrhythmias and hypertension when sympathomimetics such as pseudoephedrine are present. Evidence is limited and the mechanism is mostly inferred from anesthetic class effects.
What this interaction means in plain words
Methoxyflurane and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Myocardial sensitization to catecholamines by the halogenated agent with additive sympathomimetic effects.
What to do
Avoid pseudoephedrine before anesthetic or analgesic methoxyflurane, and monitor ECG and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Methoxyflurane with Pseudoephedrine?
MediHelp rates the interaction as moderate. Methoxyflurane and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxyflurane can sensitize the myocardium to catecholamines, which may lead to ventricular arrhythmias and hypertension when sympathomimetics such as pseudoephedrine are present. Evidence is limited and the mechanism is mostly inferred from anesthetic class effects.
How serious is the interaction between Methoxyflurane and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pseudoephedrine before anesthetic or analgesic methoxyflurane, and monitor ECG and blood pressure.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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