Drug interactions
Methoxyflurane + Streptomycin
Severity: Major
Methoxyflurane and Streptomycin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane releases fluoride during metabolism and can cause dose-related renal tubular toxicity. Combined with streptomycin, the risk of kidney injury increases, and reduced clearance may raise aminoglycoside exposure and the risk of ototoxicity.
What this interaction means in plain words
Methoxyflurane and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from fluoride-mediated tubular injury and aminoglycoside tubular accumulation.
What to do
Avoid the combination where possible, particularly with anesthetic-dose methoxyflurane. If both are required, monitor renal function and streptomycin levels closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Streptomycin
Frequently asked questions
Can I take Methoxyflurane with Streptomycin?
MediHelp rates the interaction as major. Methoxyflurane and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methoxyflurane releases fluoride during metabolism and can cause dose-related renal tubular toxicity. Combined with streptomycin, the risk of kidney injury increases, and reduced clearance may raise aminoglycoside exposure and the risk of ototoxicity.
How serious is the interaction between Methoxyflurane and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly with anesthetic-dose methoxyflurane. If both are required, monitor renal function and streptomycin levels closely.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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