Drug interactions
Methyclothiazide + Naproxen
Severity: Moderate
Methyclothiazide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effect of thiazide diuretics and, together with a diuretic, raise the risk of acute kidney injury, especially in older or volume-depleted patients. Blood pressure control may worsen with regular NSAID use.
What this interaction means in plain words
Methyclothiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, causing sodium and water retention and reduced renal perfusion, which opposes thiazide effects.
What to do
Monitor blood pressure, renal function and electrolytes when an NSAID is used regularly with the thiazide. Keep patients hydrated and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Methyclothiazide with Naproxen?
MediHelp rates the interaction as moderate. Methyclothiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effect of thiazide diuretics and, together with a diuretic, raise the risk of acute kidney injury, especially in older or volume-depleted patients. Blood pressure control may worsen with regular NSAID use.
How serious is the interaction between Methyclothiazide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes when an NSAID is used regularly with the thiazide. Keep patients hydrated and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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