Drug interactions
Methyclothiazide + Quinine
Severity: Minor
Methyclothiazide and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are handled by renal tubular secretion, so thiazides may modestly reduce quinine clearance. The clinical effect is small and poorly documented. Thiazide-induced hypokalemia or hypomagnesemia could also add to quinine's QT liability.
What this interaction means in plain words
Methyclothiazide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion of cationic drugs; thiazide-related electrolyte loss may add to QT risk.
What to do
No routine dose change is needed. Check potassium and magnesium when quinine is given to patients on thiazide diuretics and correct deficits.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Methyclothiazide with Quinine?
MediHelp rates the interaction as minor. Methyclothiazide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are handled by renal tubular secretion, so thiazides may modestly reduce quinine clearance. The clinical effect is small and poorly documented. Thiazide-induced hypokalemia or hypomagnesemia could also add to quinine's QT liability.
How serious is the interaction between Methyclothiazide and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Check potassium and magnesium when quinine is given to patients on thiazide diuretics and correct deficits.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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