Drug interactions
Methyclothiazide + Repaglinide
Severity: Minor
Methyclothiazide and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce glycemic control, particularly at higher doses. This may blunt the effect of repaglinide in patients with type 2 diabetes.
What this interaction means in plain words
Methyclothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides cause hypokalemia and impaired insulin secretion and may reduce peripheral insulin sensitivity, opposing the hypoglycemic action of repaglinide.
What to do
Monitor blood glucose after starting or changing the thiazide dose and correct potassium. Increase the antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Methyclothiazide with Repaglinide?
MediHelp rates the interaction as minor. Methyclothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and reduce glycemic control, particularly at higher doses. This may blunt the effect of repaglinide in patients with type 2 diabetes.
How serious is the interaction between Methyclothiazide and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the thiazide dose and correct potassium. Increase the antidiabetic therapy if control worsens.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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