Drug interactions
Methyclothiazide + Sacubitril-valsartan
Severity: Minor
Methyclothiazide and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics lower serum potassium while sacubitril-valsartan tends to raise it, so potassium effects partly offset each other. Additive blood pressure lowering and volume depletion can occur, which may impair renal function or cause hypotension.
What this interaction means in plain words
Methyclothiazide and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced renal potassium loss counters the reduced aldosterone-mediated potassium excretion from angiotensin receptor blockade; both also contribute additive hypotension and volume depletion.
What to do
The combination is commonly used; monitor blood pressure, serum potassium, sodium and creatinine after initiation or dose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Methyclothiazide with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Methyclothiazide and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics lower serum potassium while sacubitril-valsartan tends to raise it, so potassium effects partly offset each other. Additive blood pressure lowering and volume depletion can occur, which may impair renal function or cause hypotension.
How serious is the interaction between Methyclothiazide and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination is commonly used; monitor blood pressure, serum potassium, sodium and creatinine after initiation or dose changes.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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