Drug interactions
Methyclothiazide + Salbutamol
Severity: Moderate
Methyclothiazide and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, and the combination may cause clinically significant hypokalemia, especially with high-dose or nebulized salbutamol. Hypokalemia raises the risk of arrhythmias, particularly in patients with heart disease.
What this interaction means in plain words
Methyclothiazide and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2-mediated intracellular potassium shift and thiazide-induced renal potassium loss.
What to do
Monitor serum potassium, especially with frequent or high-dose salbutamol use, and supplement potassium or adjust therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methyclothiazide and Salbutamol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Salbutamol
Frequently asked questions
Can I take Methyclothiazide with Salbutamol?
MediHelp rates the interaction as moderate. Methyclothiazide and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, and the combination may cause clinically significant hypokalemia, especially with high-dose or nebulized salbutamol. Hypokalemia raises the risk of arrhythmias, particularly in patients with heart disease.
How serious is the interaction between Methyclothiazide and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with frequent or high-dose salbutamol use, and supplement potassium or adjust therapy as needed.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
