Drug interactions
Methyclothiazide + Salmeterol
Severity: Moderate
Methyclothiazide and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics lower potassium and beta-2 agonists can shift potassium into cells, so together they may cause clinically significant hypokalemia. Hypokalemia raises the risk of arrhythmias, especially at higher beta-agonist doses.
What this interaction means in plain words
Methyclothiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from renal potassium loss and beta-2 mediated intracellular potassium shift.
What to do
Check serum potassium and magnesium at baseline and periodically, and replace as needed. Take extra care in patients with cardiac disease or on other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Methyclothiazide with Salmeterol?
MediHelp rates the interaction as moderate. Methyclothiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics lower potassium and beta-2 agonists can shift potassium into cells, so together they may cause clinically significant hypokalemia. Hypokalemia raises the risk of arrhythmias, especially at higher beta-agonist doses.
How serious is the interaction between Methyclothiazide and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically, and replace as needed. Take extra care in patients with cardiac disease or on other QT-prolonging drugs.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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