Drug interactions
Methyclothiazide + Spironolactone
Severity: Minor
Methyclothiazide and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone retains potassium whereas thiazides waste it, so the pair is commonly used to offset potassium changes. Combined diuresis can still lead to hyponatremia, volume depletion or fluctuating potassium.
What this interaction means in plain words
Methyclothiazide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on distal renal potassium excretion with additive sodium and water loss.
What to do
Check serum potassium, sodium and renal function periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Methyclothiazide with Spironolactone?
MediHelp rates the interaction as minor. Methyclothiazide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Spironolactone retains potassium whereas thiazides waste it, so the pair is commonly used to offset potassium changes. Combined diuresis can still lead to hyponatremia, volume depletion or fluctuating potassium.
How serious is the interaction between Methyclothiazide and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium, sodium and renal function periodically.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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