Drug interactions
Methyclothiazide + Tolmetin
Severity: Moderate
Methyclothiazide and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive and diuretic effect of thiazides and increase the risk of acute kidney injury in volume-depleted patients. Potassium effects oppose each other and are unpredictable.
What this interaction means in plain words
Methyclothiazide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing thiazide action.
What to do
Monitor blood pressure, renal function, and electrolytes, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Methyclothiazide with Tolmetin?
MediHelp rates the interaction as moderate. Methyclothiazide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive and diuretic effect of thiazides and increase the risk of acute kidney injury in volume-depleted patients. Potassium effects oppose each other and are unpredictable.
How serious is the interaction between Methyclothiazide and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function, and electrolytes, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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