Drug interactions
Methyl aminolevulinate + Minocycline
Severity: Moderate
Methyl aminolevulinate and Minocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause photosensitivity, so systemic minocycline may increase phototoxic reactions at skin treated with methyl aminolevulinate photodynamic therapy. Topical absorption is low, but the local photosensitizing effect is still of concern.
What this interaction means in plain words
Methyl aminolevulinate and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitization from porphyrin accumulation and tetracycline phototoxicity.
What to do
Consider postponing photodynamic therapy until minocycline can be stopped if feasible. Otherwise counsel on light protection and watch for severe local reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methyl aminolevulinate and Minocycline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Frequently asked questions
Can I take Methyl aminolevulinate with Minocycline?
MediHelp rates the interaction as moderate. Methyl aminolevulinate and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause photosensitivity, so systemic minocycline may increase phototoxic reactions at skin treated with methyl aminolevulinate photodynamic therapy. Topical absorption is low, but the local photosensitizing effect is still of concern.
How serious is the interaction between Methyl aminolevulinate and Minocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider postponing photodynamic therapy until minocycline can be stopped if feasible. Otherwise counsel on light protection and watch for severe local reactions.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
