Drug interactions
Methyldopa + Mipomersen
Severity: Moderate
Methyldopa and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes and cause liver injury. Using them together may increase hepatotoxicity risk, and mipomersen carries a boxed warning for hepatotoxicity.
What this interaction means in plain words
Methyldopa and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity from two agents that can each cause hepatocellular injury.
What to do
Monitor ALT, AST and bilirubin at baseline and regularly during combined use. Stop one agent if liver enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Frequently asked questions
Can I take Methyldopa with Mipomersen?
MediHelp rates the interaction as moderate. Methyldopa and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes and cause liver injury. Using them together may increase hepatotoxicity risk, and mipomersen carries a boxed warning for hepatotoxicity.
How serious is the interaction between Methyldopa and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin at baseline and regularly during combined use. Stop one agent if liver enzymes rise significantly.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
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