Drug interactions
Methylenedioxymethamphetamine + Morphine
Severity: Moderate
Methylenedioxymethamphetamine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is an illicit substance with serotonergic and sympathomimetic effects, and the combination with opioids is unpredictable. Stimulation may mask opioid sedation, risking respiratory depression once the stimulant wears off.
What this interaction means in plain words
Methylenedioxymethamphetamine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS stimulant and depressant effects, with a possible minor serotonergic contribution; not well characterized.
What to do
Counsel against combined use and monitor respiratory status and temperature if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Morphine?
MediHelp rates the interaction as moderate. Methylenedioxymethamphetamine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is an illicit substance with serotonergic and sympathomimetic effects, and the combination with opioids is unpredictable. Stimulation may mask opioid sedation, risking respiratory depression once the stimulant wears off.
How serious is the interaction between Methylenedioxymethamphetamine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel against combined use and monitor respiratory status and temperature if exposure occurs.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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