Drug interactions
Methylenedioxymethamphetamine + Salmeterol
Severity: Major
Methylenedioxymethamphetamine and Salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA causes marked sympathomimetic stimulation with tachycardia, hypertension and hyperthermia, and salmeterol adds beta-adrenergic cardiac effects. The combination may increase the risk of arrhythmia and cardiovascular strain.
What this interaction means in plain words
Methylenedioxymethamphetamine and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive adrenergic stimulation, with MDMA releasing catecholamines and salmeterol activating beta receptors.
What to do
Advise patients to avoid MDMA use while on salmeterol. If exposure occurs, monitor heart rate, blood pressure, temperature and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Salmeterol?
MediHelp rates the interaction as major. Methylenedioxymethamphetamine and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MDMA causes marked sympathomimetic stimulation with tachycardia, hypertension and hyperthermia, and salmeterol adds beta-adrenergic cardiac effects. The combination may increase the risk of arrhythmia and cardiovascular strain.
How serious is the interaction between Methylenedioxymethamphetamine and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid MDMA use while on salmeterol. If exposure occurs, monitor heart rate, blood pressure, temperature and ECG.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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