Drug interactions
Methylergonovine + Minocycline
Severity: Minor
Methylergonovine and Minocycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotism with ergot alkaloids is well described with CYP3A4-inhibiting antibiotics such as macrolides, but minocycline is not one of them. An interaction with methylergonovine is poorly supported and mostly theoretical.
What this interaction means in plain words
Methylergonovine and Minocycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism for an interaction.
What to do
No empiric dose change is needed. Monitor for vasospasm symptoms such as limb coldness, paresthesia or chest pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Frequently asked questions
Can I take Methylergonovine with Minocycline?
MediHelp rates the interaction as minor. Methylergonovine and Minocycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergotism with ergot alkaloids is well described with CYP3A4-inhibiting antibiotics such as macrolides, but minocycline is not one of them. An interaction with methylergonovine is poorly supported and mostly theoretical.
How serious is the interaction between Methylergonovine and Minocycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for vasospasm symptoms such as limb coldness, paresthesia or chest pain.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
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