Drug interactions
Methylergonovine + Pimavanserin
Severity: Minor
Methylergonovine and Pimavanserin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine has serotonergic receptor activity, and pimavanserin acts on serotonin receptors and is an antipsychotic. A serotonin-related or neuroleptic-type reaction is theoretically possible, but there is little clinical evidence for this combination. Methylergonovine exposure is also increased by CYP3A4 inhibitors, but pimavanserin is not one.
What this interaction means in plain words
Methylergonovine and Pimavanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive serotonergic receptor effects; the mechanism is not well established.
What to do
No routine change is needed; be alert for features of serotonin toxicity such as agitation, tremor and hyperthermia during short-term postpartum use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Methylergonovine with Pimavanserin?
MediHelp rates the interaction as minor. Methylergonovine and Pimavanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylergonovine has serotonergic receptor activity, and pimavanserin acts on serotonin receptors and is an antipsychotic. A serotonin-related or neuroleptic-type reaction is theoretically possible, but there is little clinical evidence for this combination. Methylergonovine exposure is also increased by CYP3A4 inhibitors, but pimavanserin is not one.
How serious is the interaction between Methylergonovine and Pimavanserin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; be alert for features of serotonin toxicity such as agitation, tremor and hyperthermia during short-term postpartum use.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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