Drug interactions
Metipranolol + Propranolol
Severity: Moderate
Metipranolol and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metipranolol eye drops are a nonselective beta-blocker with some systemic absorption. With oral propranolol, additive beta-blockade can cause bradycardia, hypotension or bronchospasm.
What this interaction means in plain words
Metipranolol and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic receptor blockade.
What to do
Monitor heart rate and blood pressure, and respiratory symptoms in patients with airway disease. Consider a non-beta-blocker glaucoma agent if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Metipranolol with Propranolol?
MediHelp rates the interaction as moderate. Metipranolol and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metipranolol eye drops are a nonselective beta-blocker with some systemic absorption. With oral propranolol, additive beta-blockade can cause bradycardia, hypotension or bronchospasm.
How serious is the interaction between Metipranolol and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and respiratory symptoms in patients with airway disease. Consider a non-beta-blocker glaucoma agent if effects occur.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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