Drug interactions
Metipranolol + Timolol
Severity: Moderate
Metipranolol and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are non-selective beta-blockers, so combining them duplicates therapy and can add to systemic beta-blockade even when both are given as eye drops. This may cause bradycardia, bronchospasm or hypotension without improved pressure control.
What this interaction means in plain words
Metipranolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Therapeutic duplication with additive non-selective beta-adrenergic blockade.
What to do
Avoid combining two beta-blockers; switch to a different class for additional intraocular pressure lowering. If used together, monitor pulse and respiratory symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Metipranolol with Timolol?
MediHelp rates the interaction as moderate. Metipranolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are non-selective beta-blockers, so combining them duplicates therapy and can add to systemic beta-blockade even when both are given as eye drops. This may cause bradycardia, bronchospasm or hypotension without improved pressure control.
How serious is the interaction between Metipranolol and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two beta-blockers; switch to a different class for additional intraocular pressure lowering. If used together, monitor pulse and respiratory symptoms.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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