Drug interactions
Metoclopramide intranasal + Morphine
Severity: Moderate
Metoclopramide intranasal and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids antagonize the gastroprokinetic action of metoclopramide, and both drugs can cause CNS depression and drowsiness. Metoclopramide may also hasten absorption of oral opioids.
What this interaction means in plain words
Metoclopramide intranasal and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-induced reduction in gastrointestinal motility opposes metoclopramide's prokinetic effect, plus additive CNS depression.
What to do
Monitor for reduced antiemetic or prokinetic effect and for increased sedation. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Metoclopramide intranasal with Morphine?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids antagonize the gastroprokinetic action of metoclopramide, and both drugs can cause CNS depression and drowsiness. Metoclopramide may also hasten absorption of oral opioids.
How serious is the interaction between Metoclopramide intranasal and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiemetic or prokinetic effect and for increased sedation. Counsel patients about driving and operating machinery.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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