Drug interactions
Metoclopramide intranasal + Nortriptyline
Severity: Moderate
Metoclopramide intranasal and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause extrapyramidal effects and, rarely, neuroleptic malignant syndrome, and tricyclics with dopamine-modulating or CNS effects may add to this. Nortriptyline may also inhibit CYP2D6 to a small degree and raise metoclopramide exposure.
What this interaction means in plain words
Metoclopramide intranasal and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and extrapyramidal effects, with possible CYP2D6-related changes in metoclopramide exposure.
What to do
Monitor for movement disorders, sedation and agitation. Reduce the metoclopramide dose or choose an alternative antiemetic if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Nortriptyline?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause extrapyramidal effects and, rarely, neuroleptic malignant syndrome, and tricyclics with dopamine-modulating or CNS effects may add to this. Nortriptyline may also inhibit CYP2D6 to a small degree and raise metoclopramide exposure.
How serious is the interaction between Metoclopramide intranasal and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for movement disorders, sedation and agitation. Reduce the metoclopramide dose or choose an alternative antiemetic if effects emerge.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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