Drug interactions
Metoclopramide intranasal + Oxazepam
Severity: Moderate
Metoclopramide intranasal and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may add to sedation, and benzodiazepines may worsen its CNS effects such as drowsiness and extrapyramidal symptoms. The additive effect on alertness can impair psychomotor performance.
What this interaction means in plain words
Metoclopramide intranasal and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; metoclopramide's central dopamine antagonism adds to benzodiazepine sedation.
What to do
Monitor for excess drowsiness and movement disorders, and counsel patients against driving. Reduce doses if sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Metoclopramide intranasal with Oxazepam?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide may add to sedation, and benzodiazepines may worsen its CNS effects such as drowsiness and extrapyramidal symptoms. The additive effect on alertness can impair psychomotor performance.
How serious is the interaction between Metoclopramide intranasal and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness and movement disorders, and counsel patients against driving. Reduce doses if sedation occurs.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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