Drug interactions
Metoclopramide intranasal + Oxybutynin
Severity: Moderate
Metoclopramide intranasal and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin's anticholinergic action opposes the prokinetic effect of metoclopramide, which depends on cholinergic stimulation of the gut. This can reduce metoclopramide efficacy in gastroparesis.
What this interaction means in plain words
Metoclopramide intranasal and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between antimuscarinic oxybutynin and the cholinergic prokinetic effect of metoclopramide.
What to do
Monitor gastroparesis symptom control and consider an alternative bladder agent if the prokinetic response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoclopramide intranasal and Oxybutynin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxybutynin
Frequently asked questions
Can I take Metoclopramide intranasal with Oxybutynin?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybutynin's anticholinergic action opposes the prokinetic effect of metoclopramide, which depends on cholinergic stimulation of the gut. This can reduce metoclopramide efficacy in gastroparesis.
How serious is the interaction between Metoclopramide intranasal and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor gastroparesis symptom control and consider an alternative bladder agent if the prokinetic response is lost.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
