Drug interactions
Metoclopramide intranasal + Scopolamine
Severity: Moderate
Metoclopramide intranasal and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide stimulates gastrointestinal motility through cholinergic and dopaminergic mechanisms, while scopolamine blocks muscarinic receptors. They oppose each other, so metoclopramide may be less effective, and both can contribute to CNS effects such as drowsiness.
What this interaction means in plain words
Metoclopramide intranasal and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of prokinetic effects by muscarinic blockade, plus additive CNS effects.
What to do
Avoid combining where possible and choose one agent based on the indication. If both are used, monitor for reduced prokinetic response and for sedation or extrapyramidal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Metoclopramide intranasal with Scopolamine?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide stimulates gastrointestinal motility through cholinergic and dopaminergic mechanisms, while scopolamine blocks muscarinic receptors. They oppose each other, so metoclopramide may be less effective, and both can contribute to CNS effects such as drowsiness.
How serious is the interaction between Metoclopramide intranasal and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose one agent based on the indication. If both are used, monitor for reduced prokinetic response and for sedation or extrapyramidal symptoms.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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