Drug interactions
Metoclopramide intranasal + Selegiline
Severity: Major
Metoclopramide intranasal and Selegiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide blocks dopamine receptors and can counteract the benefit of selegiline in Parkinson disease, worsening motor symptoms. Metoclopramide may also add to the hypertensive effect of MAO inhibitors.
What this interaction means in plain words
Metoclopramide intranasal and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Central D2 receptor antagonism opposes dopaminergic therapy, and catecholamine release adds to MAO inhibitor pressor effects.
What to do
Avoid the combination in Parkinson disease. Use an antiemetic without central dopamine antagonism, and monitor blood pressure if exposure cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Selegiline?
MediHelp rates the interaction as major. Metoclopramide intranasal and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide blocks dopamine receptors and can counteract the benefit of selegiline in Parkinson disease, worsening motor symptoms. Metoclopramide may also add to the hypertensive effect of MAO inhibitors.
How serious is the interaction between Metoclopramide intranasal and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in Parkinson disease. Use an antiemetic without central dopamine antagonism, and monitor blood pressure if exposure cannot be avoided.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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