Drug interactions
Metrizamide + Selegiline
Severity: Moderate
Metrizamide and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metrizamide is an intrathecal contrast agent that lowers the seizure threshold. Concurrent drugs that also lower the seizure threshold or alter CNS function may add to this risk, so the legacy guidance was to interrupt the MAO inhibitor beforehand.
What this interaction means in plain words
Metrizamide and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism not firmly established; likely additive lowering of the seizure threshold.
What to do
Withhold the MAO inhibitor for about 24 hours before myelography where clinically feasible. Monitor for seizures afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Metrizamide with Selegiline?
MediHelp rates the interaction as moderate. Metrizamide and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metrizamide is an intrathecal contrast agent that lowers the seizure threshold. Concurrent drugs that also lower the seizure threshold or alter CNS function may add to this risk, so the legacy guidance was to interrupt the MAO inhibitor beforehand.
How serious is the interaction between Metrizamide and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold the MAO inhibitor for about 24 hours before myelography where clinically feasible. Monitor for seizures afterwards.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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