Drug interactions
Metronidazole + Nilotinib
Severity: Moderate
Metronidazole and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a CYP3A4 substrate with dose-related QT prolongation, so any rise in its levels is a concern. Metronidazole is itself associated with rare QT prolongation, adding a possible pharmacodynamic contribution.
What this interaction means in plain words
Metronidazole and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Nilotinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by metronidazole may raise nilotinib levels, with possible additive QT effects.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes (potassium, magnesium) during co-administration. Consider an alternative antimicrobial if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metronidazole and Nilotinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Metronidazole with Nilotinib?
MediHelp rates the interaction as moderate. Metronidazole and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a CYP3A4 substrate with dose-related QT prolongation, so any rise in its levels is a concern. Metronidazole is itself associated with rare QT prolongation, adding a possible pharmacodynamic contribution.
How serious is the interaction between Metronidazole and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes (potassium, magnesium) during co-administration. Consider an alternative antimicrobial if the QTc lengthens.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
