Drug interactions
Metronidazole + Pazopanib
Severity: Minor
Metronidazole and Pazopanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is a CYP3A4 substrate, and strong inhibitors raise its exposure, increasing hepatotoxicity and QT risk. Metronidazole is not a strong CYP3A4 inhibitor, so the labeled dose reduction for strong inhibitors does not apply, but a small increase is possible.
What this interaction means in plain words
Metronidazole and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Pazopanib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole modestly reducing pazopanib metabolism.
What to do
No dose reduction is required; monitor liver function tests and watch for QT-related symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Metronidazole with Pazopanib?
MediHelp rates the interaction as minor. Metronidazole and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pazopanib is a CYP3A4 substrate, and strong inhibitors raise its exposure, increasing hepatotoxicity and QT risk. Metronidazole is not a strong CYP3A4 inhibitor, so the labeled dose reduction for strong inhibitors does not apply, but a small increase is possible.
How serious is the interaction between Metronidazole and Pazopanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose reduction is required; monitor liver function tests and watch for QT-related symptoms.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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