Drug interactions
Metronidazole + Repaglinide
Severity: Minor
Metronidazole and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is cleared by CYP2C8 and CYP3A4, and increased exposure can cause hypoglycemia. Metronidazole is only a weak inhibitor, so a clinically relevant effect is uncertain.
What this interaction means in plain words
Metronidazole and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Repaglinide belongs to Endocrine.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing repaglinide metabolism.
What to do
Advise closer self-monitoring of blood glucose during metronidazole therapy and adjust repaglinide only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Metronidazole with Repaglinide?
MediHelp rates the interaction as minor. Metronidazole and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide is cleared by CYP2C8 and CYP3A4, and increased exposure can cause hypoglycemia. Metronidazole is only a weak inhibitor, so a clinically relevant effect is uncertain.
How serious is the interaction between Metronidazole and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise closer self-monitoring of blood glucose during metronidazole therapy and adjust repaglinide only if hypoglycemia occurs.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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