Drug interactions
Metronidazole + Suvorexant
Severity: Moderate
Metronidazole and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may increase suvorexant exposure through CYP3A4 inhibition, leading to greater next-day somnolence and impaired driving ability.
What this interaction means in plain words
Metronidazole and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Suvorexant belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by metronidazole reduces suvorexant clearance.
What to do
Start suvorexant at 5 mg at bedtime when used with metronidazole and titrate cautiously. Counsel on daytime drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Metronidazole with Suvorexant?
MediHelp rates the interaction as moderate. Metronidazole and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metronidazole may increase suvorexant exposure through CYP3A4 inhibition, leading to greater next-day somnolence and impaired driving ability.
How serious is the interaction between Metronidazole and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at 5 mg at bedtime when used with metronidazole and titrate cautiously. Counsel on daytime drowsiness and driving.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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