Drug interactions
Metronidazole + Tolterodine
Severity: Minor
Metronidazole and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole has weak CYP3A4 inhibitory effects and may slightly raise tolterodine levels. Metronidazole can also prolong the QT interval rarely. The clinical effect is generally small.
What this interaction means in plain words
Metronidazole and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Tolterodine belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4-mediated tolterodine metabolism.
What to do
No dose adjustment is usually needed. Monitor for increased anticholinergic effects, and consider an ECG in patients with QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metronidazole with Tolterodine?
MediHelp rates the interaction as minor. Metronidazole and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole has weak CYP3A4 inhibitory effects and may slightly raise tolterodine levels. Metronidazole can also prolong the QT interval rarely. The clinical effect is generally small.
How serious is the interaction between Metronidazole and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for increased anticholinergic effects, and consider an ECG in patients with QT risk factors.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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